B+ Surface
B for Biology.
B+ is a biological feature of MIS implants, that results in effective, long-term osseointegration.
A mono-molecular layer of multi phosphonates is permanently bound to the surface of the implant, which is perceived as bone-like by the body.
Current literature demonstrates a linkage between improved bone healing and early osseointegration with the hydrophilicity of surface.
B+ enhances the wettability of the implant surface, attracting water, proteins, and cells from the blood, enabling quicker cell adhesion and colonization, which results in faster bone matrix formation and osseointegration. The bone cells perceive the B+ treated implants as “bone” and thus migrate onto these surfaces very quickly.
Biomechanical Fixation
Once on the implant surface, a new bone matrix is quickly formed, maturing to organized, mineralized bone. The biomimetic characteristics of B+ allow for greater implant integration at earlier stages leading to long-term optimal osseointegration. The increased number of bone cells in contact with the B+ implant results in enhanced biomechanical implant fixation very early on in the healing process. Increased fixation with B+ has been observed to reduce healing time.
Elimination of the “Micro-Gap”
In addition to mechanical interlocking resulting from the implant’s roughened topography, B+ also provides a chemical connection between bone and implant surface, eliminating the “micro-gap”. This results in early functional implant stability and fixation.
Stability in a Physiological Environment
The B+ molecule was shown to remain permanently bound to the implant surface throughout osseointegration, inflammation, and remodeling events. Furthermore unlike phosphates, phosphonated molecules such as B+ are enzymatically stable, ensuring that B+ will remain attached to the implant, and will not be released into the body over time.
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